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Graph Schema

Module vs Graph schema​

The backend graph database schema is specified by the graph schema. However, it is rather complex and not easily understandable by the user. Therefore, the module schema is a simplified version of the graph schema that is easier to understand.

Module schema​

The module schema groups sections of the graph schema together.

For example, the Tcr module contains the following nodes:

  • TCR
  • VAlpha
  • VBeta
  • JAlpha
  • JBeta
  • Cdr3Alpha
  • Cdr3Beta

Graph schema​

graph schema

Nodes references​

  • VAlpha: Represents the variable region of the T-cell receptor alpha chain.
  • JAlpha: Represents the joining region of the T-cell receptor alpha chain.
  • Cdr3Alpha: Represents the complementarity-determining region 3 of the T-cell receptor alpha chain.
  • VBeta: Represents the variable region of the T-cell receptor beta chain.
  • JBeta: Represents the joining region of the T-cell receptor beta chain.
  • Cdr3Beta: Represents the complementarity-determining region 3 of the T-cell receptor beta chain.
  • Tra: Represents the T-cell receptor alpha chain.
  • Trb: Represents the T-cell receptor beta chain.
  • Tcr: Represents the T-cell receptor, which is composed of both alpha and beta chains.
  • Clone: Represents a T-cell clone, which is a group of T-cells with identical T-cell receptors.
  • MhcA: Represents the major histocompatibility complex class I alpha chain.
  • MhcB: Represents the major histocompatibility complex class II beta chain.
  • Mhc: Represents the major histocompatibility complex, which is involved in antigen presentation.
  • Epitope: Represents the part of an antigen that is recognized by the immune system.
  • PMhc: Represents the peptide-MHC complex, which is the combination of a peptide and an MHC molecule.
  • Annotation: Represents additional information or metadata associated with other nodes.
  • Species: Represents the species from which the T-cell receptor data is derived.
  • Individual: Represents an individual organism from which the T-cell receptor data is derived.
  • Repertoire: Represents the collection of T-cell receptors from an individual or study.
  • Study: Represents a research study that generated the T-cell receptor data.
  • Database: Represents the database that stores the T-cell receptor data.